Fluorine-containing antifolates incapable of polyglutamate formation
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United States of America Patent
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Apr 22, 1986
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N/A
app pub date -
Aug 21, 1984
filing date -
Aug 21, 1984
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Expired
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Abstract
A methotrexate derivative having the following general formula is incapable of forming polyglutamate and thus is expected to have reduced cytotoxicity associated with the formation of polyglutamate derivatives in a living cell, ##STR1## wherein n is from 0 to 5.
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