Method for preparing medetomidine and its salts
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United States of America Patent
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Mar 8, 2011
Grant Date -
Feb 25, 2010
app pub date -
Nov 2, 2007
filing date -
Nov 6, 2006
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Abstract
The invention provides an improved, highly efficient method for preparing Medetomidine, and its salts, in particular its pharmaceutically acceptable salts. The method utilizes the high reactivity of halogenated imidazoles towards transmetalation with Grignard reagents and the subsequent reaction with 2,3-dimethylbenzaldehyde.
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