Linear polyethylenimine-sterol conjugates for gene delivery
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United States of America Patent
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Jan 4, 2011
Grant Date -
Jul 5, 2007
app pub date -
Feb 27, 2007
filing date -
Jul 17, 2002
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Abstract
Linear polyethylenimine was modified with sterols, such as cholesterol, in three different geometries: linear shaped (L), T-shaped (T), and a combined linear- and T-shaped (LT), to result in linear polyethylenimine-sterol conjugates. These conjugates were mixed with nucleic acids to form complexes for delivery of the nucleic acids into cells. Mammalian cells transfected with these complexes showed protein expression levels higher than linear polyethylenimine alone, and twice that of branched polyethylenimine, but without any significant loss in cell viability. Methods of making these compositions and methods of using them for gene delivery are also described.
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