Use of substituted N, N-disubstituted diamino compounds for inhibiting cholesteryl ester transfer protein activity

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United States of America Patent

PATENT NO 6479552
APP PUB NO 20020120011A1
SERIAL NO

09991174

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Preferred tertiary-heteroalkylamine compounds are substituted N,N-disubstituted diamines. A preferred specific N,N-disubstituted diamine is the compound: ##STR1##

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Patent Owner(s)

  • G.D. SEARLE & CO.

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Durley, Richard C Chesterfield, MO 56 534
Fobian, Yvette M Labadie, MO 57 383
Grapperhaus, Margaret L Troy, IL 44 218
Hamme, Ashton T St. Louis, MO 39 196
Hickory, Brian S Wildwood, MO 45 397
Massa, Mark A Ballwin, MO 46 213
Mischke, Deborah A Defiance, MO 66 386
Norton, Monica B St. Louis, MO 45 219
Parnas, Barry L University City, MO 32 187
Promo, Michele A Chesterfield, MO 40 313
Reinhard, Emily J Chesterfield, MO 43 217
Rueppel, Melvin L St. Louis, MO 71 344
Sikorski, James A Des Peres, MO 159 932
Spangler, Dale P Deerfield, IL 55 304
Tollefson, Michael B O'Fallon, MO 52 267
Vernier, William F St. Louis, MO 48 247
Wang, Lijuan Wildwood, MO 89 1734

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