Method and apparatus for determining the efficacy of statins for treating inflammatory diseases in individual patients

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United States of America Patent

PATENT NO 11531036
APP PUB NO 20200191807A1
SERIAL NO

16608428

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A method, device, computer program and related immunoassay are disclosed for assessing the efficacy of a statin selected from, for example, selected from RvT1 (7,13,20-trihydroxy-8,10,14,16Z,18-docosapentaenoic acid), RvT2 (7,12,13-trihydroxy-8,10,14,16Z,19Z-docosapentaenoic acid), RvT3 (7,8,13-trihydroxy-9,11,14,16Z,19Z-docosapentaenoic acid) and RvT4 (7,13-dihydroxy-8,10,14,16Z,19Z-docosapentaenoic acid), for use in the treatment of an inflammatory condition in an individual patient, which comprises measuring the levels of at least one 13-series resolvin in biological samples obtained from the patient before and after administration of the statin, wherein an increase in the level of the resolvin after administration of the statin is indicative of efficacy of the statin. Also disclosed is a method of storing a biological sample to preserve lipid mediators in the sample comprising placing the sample in an organic solvent and storing the sample at a temperature of ≤−75° C.

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Patent Owner(s)

  • QUEEN MARY UNIVERSITY OF LONDON

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Colas, Romain Alexandre London, GB 3 0
Dalli, Jesmond London, GB 10 10
Soares, De Souza Patricia Regina London, GB 1 0
Walker, Mary Elizabeth London, GB 1 0

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