Antibody that specifically binds to the cadherin-5 cell adhesion recognition sequence
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United States of America Patent
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May 27, 2003
Grant Date -
N/A
app pub date -
Apr 20, 2001
filing date -
May 5, 1998
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Modulating agents for inhibiting or enhancing nonclassical cadherin mediated cell adhesion are provided. The modulating agents comprise one or more of: (a) a peptide sequence that is at least 50% identical to a nonclassical cadherin CAR sequence; (b) a non-peptide mimetic of a nonclassical cadherin CAR sequence; (c) a substance, such as an antibody or antigen-binding fragment thereof, that specifically binds a nonclassical cadherin CAR sequence; and/or (d) a polynucleotide encoding a polypeptide that comprises a nonclassical cadherin CAR sequence or analogue thereof. Methods for using such modulating agents for modulating nonclassical cadherin-mediated cell adhesion in a variety of contexts are also provided.
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