Methods for proteome labeling

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United States of America Patent

PATENT NO 11921118
APP PUB NO 20210172959A1
SERIAL NO

17090261

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Abstract

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Provided herein are methods for labeling the proteomes of cells, as well as methods for labeling proteins or populations of proteins produced by cells. In some embodiments, the methods comprise introducing variant aminoacyl-tRNA synthetases and noncanonical amino acids into cells. Also provided herein are polynucleotides encoding variant aminoacyl-tRNA synthetases that recognize noncanonical amino acids. The methods and compositions provided herein are useful for, among other things, identifying target cells and identifying biomarkers of interest.

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Patent Owner(s)

  • THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY; THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Brewer, Kyle Stanford, US 2 0
Wyss-Coray, Anton Stanford, US 41 459
Yang, Andrew Stanford, US 69 2031

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