Polyhydro derivatives of tylosine and process for their preparation
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United States of America Patent
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Jul 13, 1999
Grant Date -
N/A
app pub date -
Oct 28, 1997
filing date -
Oct 30, 1996
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention relates to 13-hydroxy-tylosine derivatives, novel semisynthetic antibiotics from the class of macrolides, and to a process for the preparation thereof. According to the present invention by a reductive opening of the oxirane ring of tylosine 13-hydroxy compounds are obtained, which are then subjected to a hydrogenation of the double bond and then 13-hydroxy dihydro or tetrahydro compounds are subjected to an oximation reaction or 13-hydroxy oximes are subjected to the hydrogenation of the double bond.
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