6-substituted-thio-2-amino-quinoline derivatives useful as inhibitors of β-secretase (BACE)
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United States of America Patent
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Dec 13, 2011
Grant Date -
Sep 10, 2009
app pub date -
Jan 27, 2009
filing date -
Jan 28, 2008
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Abstract
The present invention is directed to 6-substituted-thio-2-amino-quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD), mild cognitive impairment, senility and/or dementia. The compounds of the present invention are inhibitors of β-secretase, also known as β-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2.
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