Method and kit for testing tumors for drug sensitivity
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United States of America Patent
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Nov 22, 1994
Grant Date -
N/A
app pub date -
Jun 9, 1992
filing date -
Jun 9, 1992
priority date (Note) -
Expired
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Abstract
Chemotherapy agents of interest are tested in untreated tumor cells and in tumor cells pretreated with buthionine sulfoximine (BSO) which reverses resistance related to elevated glutathione levels, and/or calcium channel blockers such as Verapamil which reduce resistance related to p-glycoprotein levels. The results of the several tests are then integrated to provide a predictor of tumor drug sensitivity and the potential utility of pretreatment regimens.
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