Hematology control compositions for three populations of leukocytes; and methods for their preparation and use in whole blood control systems
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United States of America Patent
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Nov 3, 1987
Grant Date -
N/A
app pub date -
May 18, 1984
filing date -
May 18, 1984
priority date (Note) -
Expired
status (Latency Note)
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Abstract
This invention primarily is directed to a hematology reference control solution, the three separate white cell control portions thereof consisting of three types of fixed red cells of determined size distribution for checking the operation of a particle analyzing instrument, including its predetermined lower and upper threshold settings for each class or subclass of leukocytes. For preparing a human granulocyte analogue, nurse shark erythrocytes are altered and fixed in a chilled solution to simulate in number, size and distribution the granulocytes in human whole blood. Such a granulocyte analogue is useful as a free-standing reference control, for determination of human granulocytes only, or can be comingled with reference controls for lymphocytes and mononuclear cells for use with multi-parameter instruments to give a trimodal leukocyte reference control, which itself can be included in a multiple-analysis hematology reference control, having components for also determining red blood cell and platelet parameters.
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