Methods and compositions for modulating CAR-T activity

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 11987628
APP PUB NO 20240002507A1
SERIAL NO

18339157

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Disclosed herein are engineered cells and/or hypoimmunogenic cells including engineered and/or hypoimmunogenic stem cells, engineered and/or hypoimmunogenic cells differentiated therefrom, engineered and/or hypoimmunogenic CAR-T cells (primary or differentiated from engineered and/or hypoimmunogenic stem cells) and related methods of their use and generation. Provided herein are engineered and/or hypoimmunogenic cells exhibiting reduced expression of MHC class I and/or MHC class II human leukocyte antigens and T-cell receptors. In some embodiments, such cells also exogenously express one or more tolerogenic factors such as CD47 and one or more chimeric antigen receptors (CAR)s.

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Patent Owner(s)

  • SANA BIOTECHNOLOGY, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fry, Terry J Denver, US 14 13
Schrepfer, Sonja San Mateo, US 20 20
Weng, Lindong Seattle, US 10 5

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