Modulation of transthyretin expression

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United States of America Patent

PATENT NO 11535849
APP PUB NO 20210095281A1
SERIAL NO

16889470

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Abstract

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Provided herein are methods, compounds, and compositions for reducing expression of transthyretin mRNA and protein in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate transthyretin amyloidosis, or a symptom thereof.

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Patent Owner(s)

  • IONIS PHARMACEUTICALS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Freier, Susan M San Diego, US 510 6168
Guo, Shuling Carlsbad, US 31 50
Monia, Brett P Encinitas, US 302 5652
Siwkowski, Andrew M Carlsbad, US 55 1270

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