Tetralin and tetrahydroquinoline compounds as inhibitors of HIF-2α

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United States of America Patent

PATENT NO 11407712
APP PUB NO 20210317079A1
SERIAL NO

17205273

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Abstract

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Compounds that inhibit HIF-2α, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2α.

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Patent Owner(s)

  • ARCUS BIOSCIENCES, INC.

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Beatty, Joel Worley San Mateo, US 4 1
Drew, Samuel Lawrie Millbrae, US 4 1
Epplin, Matthew South San Francisco, US 7 2
Fournier, Jeremy Thomas Andre Fremont, US 2 1
Gal, Balint Hayward, US 4 1
Guney, Tezcan Hayward, US 13 12
Haelsig, Karl T Berkeley, US 2 1
Hardman, Clayton San Francisco, US 6 2
Jacob, Steven Donald Oakland, US 4 1
Jeffrey, Jenna Leigh Oakland, US 6 4
Kalisiak, Jaroslaw Mountain View, US 32 147
Lawson, Kenneth Victor San Francisco, US 3 1
Leleti, Manmohan Reddy Dublin, US 69 558
Lindsey, Erick Allen San Diego, US 10 30
Mailyan, Artur Karenovich Hayward, US 3 1
Mandal, Debashis Fremont, US 13 20
Mata, Guillaume Berkeley, US 3 1
Moon, Hyunyoung Foster City, US 2 1
Powers, Jay Patrick Pacifica, US 38 125
Rosen, Brandon Reid San Mateo, US 13 33
Su, Yongli Foster City, US 6 14
Tran, Anh Thu Union City, US 5 2
Wang, Zhang Petaluma, US 8 32
Yan, Xuelei Foster City, US 40 165
Yu, Kai Hayward, US 98 1142

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