Modified HSV gD protein and vaccine containing same

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United States of America Patent

PATENT NO 11357847
APP PUB NO 20210205441A1
SERIAL NO

16641420

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Abstract

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The modified HSV gD protein of the present invention is a modified protein of a herpes simplex virus (HSV) envelope glycoprotein D (gD), wherein the modified HSV gD protein is derived from a wild-type HSV gD by modification of at least one of B cell epitopes having low or no neutralizing antibody-inducing activity compared to a B cell epitope present in a receptor-binding domain (RBD) (decotopes) in the ectodomain of the wild-type HSV gD, so that the modified epitope does not function as an epitope.

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Patent Owner(s)

  • KM BIOLOGICS CO., LTD.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Katayama, Takahiro Kawasaki, JP 37 480
Koube, Akihiro Kikuyo-machi, JP 3 2
Mori, Hiroaki Kumamoto, JP 66 412
Nishimura, Tomohiro Kumamoto, JP 26 88
Shimizu, Hiroyuki Ageo, JP 159 1426

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