Protein kinase deficient, immunologically active CMVpp65 mutants
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United States of America Patent
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Jun 17, 2008
Grant Date -
Jan 26, 2006
app pub date -
Aug 18, 2005
filing date -
Mar 23, 2000
priority date (Note) -
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Abstract
This invention relates to mutated CMVpp65, a viral structural protein which activates cell mediated immunity in humans infected with CMV. The mutations remove undesirable protein kinase activity naturally present in the protein and make it suitable for the production of both DNA and protein vaccines. Therefore, the invention provides proteins and DNAS, as well as vaccines comprising the proteins and DNAs, including cellular vaccines and vectors. Other embodiments of the invention relate to methods of enhancing immune response and vaccinating against CMV, including gene therapy methods and vectors.
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