Phospholipase A.sub.2-inhibitory peptide with anti-arthritic and neuroprotective activities
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United States of America Patent
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Feb 13, 2007
Grant Date -
Mar 31, 2005
app pub date -
Apr 30, 2004
filing date -
Apr 30, 2003
priority date (Note) -
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Abstract
Peptides that have potent PLA.sub.2-inhibitory activity are disclosed. Homology searches of known PLA inhibitory molecules were used to identify and subsequently design potent peptide molecules that can induce neuroprotective as well as anti-inflammatory effect. These peptides were shown to protect against degeneration of joints in transgenic mouse model prone to arthritis. Protection from kainate-induced excitotoxic neuronal injury was also observed using these peptides. These peptides, their analogs and derivatives have potential as neuroprotective and/or anti-inflammatory agents in a clinical setting.
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