Combination therapy with notch and PD-1 or PD-L1 inhibitors

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United States of America Patent

PATENT NO 11826317
SERIAL NO

16870853

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Abstract

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The present invention provides medicaments for use in treating and methods of treating T-cell acute lymphoblastic leukemia, acute lymphoblastic leukemia, chronic lymphoblastic leukemia, acute myelogenous leukemia, chronic myelogenous leukemia, erythroleukemia, triple negative breast cancer, breast cancer, ovarian cancer, melanoma, Sung cancer, non small-cell lung cancer, pancreatic cancer, glioblastoma, colorectal cancer, head and neck cancer, cervical cancer, prostate cancer, liver cancer, oral squamous cell carcinoma, skin cancer, medul!ob!astoma, hepatocellular carcinoma, intrahepatic and extrahepatic cholangiocarcinoma, desmoid tumor, soft tissue sarcoma, or adenoid cystic carcinoma in a patient comprising combination therapy with 4,4,4-tri-fluoro-N-[(1S)-2˜[[(7S)-5-(2-hydroxyemyl)-6-oxo-7H-pyrido[23-d][3]benzazepin-7-yl]amino]-1-methyl-2-oxo-ethyljbutanamide, or a pharmaceutically acceptable salt or hydrate thereof, and a PD-1 or a PD-L1 inhibitor selected from pembrolizumab, nivolumab, atezolizumab, durvalumab, and avelumab.

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Patent Owner(s)

Patent OwnerAddress
ELI LILLY AND COMPANYLILLY CORPORATE CENTER PATENT DIVISION INDIANAPOLIS IN 46285

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bender, Mark Harrath Indianapolis, US 2 12
Gao, Hong Indianapolis, US 134 629
Patel, Bharvin Kumar Indianapolis, US 12 159

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