Antibody-drug conjugates targeting human Claudin 18.2

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United States of America Patent

PATENT NO 11554177
SERIAL NO

17530209

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Abstract

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Provided are antibody-drug conjugates containing a drug moiety attached to an antibody or fragment thereof having binding specificity to the wild-type human claudin 18.2 (CLDN18.2) protein. The antibody or the fragment thereof binds to the β3-β4 loop (residues 45-63 of SEQ ID NO: 30, NYQGLWRSCVRESSGFTEC) and the β5 strand (residues 169-172 of SEQ ID NO: 30, YTFG) of CLDN18.2.

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Patent Owner(s)

  • LANOVA MEDICINES LIMITED COMPANY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Li, RunSheng Shanghai, CN 15 2

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