Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines
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United States of America Patent
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Aug 31, 2004
Grant Date -
Oct 30, 2003
app pub date -
Mar 10, 2003
filing date -
Mar 12, 2002
priority date (Note) -
Expired
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Abstract
A process for making an N1-(2'-pyridyl)-1,2-alkanediamine sulfamic acid of formula II by reacting a compound of formula I with NH.sub.2 R' ##STR1## wherein R and R' are as defined in the specification. The invention also includes the compound of formula II, and optical isomers thereof. The compound of formula II is an intermediate useful for making chiral piperazine derivatives which are active at the 5-HT.sub.1A receptor.
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