Therapeutic retroviral vectors for gene therapy
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United States of America Patent
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Mar 8, 2011
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app pub date -
Jun 9, 2005
filing date -
Dec 13, 2002
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Abstract
The invention provides improved compositions and methods for achieving gene therapy in hematopoietic cells and hematopoietic precursor cells, including erythrocytes, erythroid progenitors, and embryonic stem cells. The invention further provides improved gene therapy methods for treating hematopoietic-related disorders. Retroviral gene therapy vectors that are optimized for erythroid specific expression and treatment of hemoglobinopathic conditions are disclosed.
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