Neutralising antibody against dengue for use in a method of prevention and/or treatment of Zika infection

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United States of America Patent

PATENT NO 11926648
APP PUB NO 20210355167A1
SERIAL NO

17241884

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Abstract

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A flavivirus Envelope Dimer Epitope (EDE) and isolated neutralizing antibody or antigen binding fragment thereof directed against the EDE for use in vaccinating an individual against one or more flaviviruses wherein the EDE is a stabilized recombinant flavivirus are provided. The dimer is: covalently stabilized with at least one disulphide inter-chain bond or one sulfhydryl-reactive crosslinker between the two sE monomers, and/or by being formed as a single polypeptide chain, and/or by linking the two sE monomers through modified sugar, and/or non-covalently stabilized by substituting at least one amino acid residue in the amino acid sequence of at least one sE monomer with at least one bulky side chain amino acid, at the dimer interface or in domain 1 (D1)/domain 3 (D3) linker of each monomer. The dimer is a homodimer or heterodimer of native and/or mutant envelope polypeptides, from DENV-1, DENV-2, DENV-3, DENV-4, Zika and/or other flavivirus.

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Patent Owner(s)

  • ETABLISSEMENT DECLARE D'UTILITE PUBLIQUE DIT. INSTITUT PASTEUR; IMPERIAL COLLEGE INNOVATIONS LIMITED

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Mongkolsapaya, Juthathip London, GB 7 0
Rey, Felix Paris, FR 4 0
Rouvinski, Alexander Jerusalem, IL 4 0
Screaton, Gavin London, GB 9 14
Spaeth, Giovanna Barba Paris, FR 2 0
Vaney, Marie-Christine Paris, FR 4 0

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