Method of identifying a modulator of a LT.beta.R complex signaling pathway
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United States of America Patent
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Sep 25, 2007
Grant Date -
Feb 26, 2004
app pub date -
Feb 10, 2003
filing date -
Feb 8, 2002
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention relates to compositions and methods comprising lymphotoxin-beta receptor (LT.beta.R) modulators, which activate or inhibit LT.beta.R signaling. LT.beta.R modulators are useful for treating lymphocyte mediated immunological diseases and cancer, and more particularly, for regulating mitochondrial-mediated apoptosis. This invention relates to soluble forms of the LT.beta.R complex proteins that act as LT.beta.R activating or inhibiting agents. This invention also relates to the use of soluble molecules, directed against either the LT.beta.R, its ligands, LIGHT and LT.beta.1.alpha.2, or its intracellular binding partners, that function to regulate LT.beta.R signaling. A novel screening method for selecting soluble receptors, antibodies and other agents that modulate LT.beta.R signaling is provided.
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