Stabilization of liquid solutions of recombinant protein for frozen storage

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United States of America Patent

PATENT NO 8187799
APP PUB NO 20100113744A1
SERIAL NO

12597333

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention relates to a method for stabilizing a bulk solution of recombinant protein for frozen storage, which comprises providing a partially-purified solution of recombinant protein which has a monovalent salt concentration of at least 100 mM, and adding a carbohydrate to said solution in an amount sufficient that, upon freezing, the solution has a glass transition temperature of −56° C. or higher.

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Patent Owner(s)

  • BAYER HEALTHCARE LLC

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Desponds, Arnaud Yverdon-les-Bains, CH 3 18
Joshi, Omkar Albany, US 11 20
Tsvetkova, Nelly Vallejo, US 7 87
Wang, Deqian Concord, US 13 115
Wu, Paul Orinda, US 19 254

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