Human monoclonal antibodies to epidermal growth factor receptor (EGFR)
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United States of America Patent
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Jul 24, 2007
Grant Date -
May 15, 2003
app pub date -
Jun 13, 2002
filing date -
Jun 13, 2001
priority date (Note) -
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Abstract
Isolated human monoclonal antibodies which specifically bind to human EGFR, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
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