Disubstituted alkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
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United States of America Patent
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May 24, 2011
Grant Date -
Mar 5, 2009
app pub date -
Aug 26, 2008
filing date -
Aug 27, 2007
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Abstract
The invention provides novel 8-azabicyclo[3.2.1]octane compounds of formula (I):where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.
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