Radiolabeled compounds targeting the prostate-specific membrane antigen

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United States of America Patent

PATENT NO 11504441
APP PUB NO 20210338851A1
SERIAL NO

17371587

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A compound comprising a prostate specific membrane antigen (PSMA)-targeting moiety of the following formula or of a salt or a solvate thereof. R0 is O or S. Each of R1a, R1b and R1c may be —CO2H, —SO2H, —SO3H, —PO2H, or —PO3H2, for example. R2 may be methylene or a derivative thereof, propylene or a derivative thereof, or a derivative of ethylene, optionally substituted. R3 is a linker. When the PSMA-targeting moiety is linked to a radiolabeling group, the compound may be used as an imaging agent or therapeutic agent for PSMA-expressing diseases/conditions.

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Patent Owner(s)

  • BC CANCER, PART OF THE PROVINCIAL HEALTH SERVICES AUTHORITY; THE UNIVERSITY OF BRITISH COLUMBIA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bénard, François Vancouver, CA 10 0
Kuo, Hsiou-Ting Sherbrooke, CA 7 6
Lin, Kuo-Shyan Richmond, CA 18 12
Perrin, David Vancouver, CA 46 206
Zhang, Zhengxing Vancouver, CA 15 7

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