Pyrazino [1'2':1,6 ] pyrido [3, 4-b] indole-1,4-dione derivatives
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United States of America Patent
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Aug 29, 2006
Grant Date -
Aug 5, 2004
app pub date -
Apr 15, 2002
filing date -
Jun 5, 2001
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Compounds of the general structural formula (I), and use of the compounds and salts and solvates thereof, as thereapeutic agents. In particular, the invention relates to compounds that are potent and selective inhibitors of cyclic guanosine 3', 5'-monophosphate specific phosphodiesterase (cGMP-specific PDE), in particular PDE5, and have utility in a variety of therapeutic areas wherein such inhibition is considered beneficial, including the treatment of cardiovascular disorders and erectile dysfunction ##STR00001##
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