Immunomodulation by IAP inhibitors

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United States of America Patent

PATENT NO 11382905
APP PUB NO 20200345714A1
SERIAL NO

16926930

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention is directed to immune adjuvants containing IAP inhibitors, including Smac mimetics. The invention further provides pharmaceutical compositions and vaccines containing an IAP inhibitor and an antigen. Methods of enhancing an immune response by administration of an IAP inhibitor, methods of treating or preventing cancer, methods of treating or preventing infections, methods of treating autoimmune disorders, and methods of potentiating cytokine or antibody production are also provided.

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Patent Owner(s)

  • NOVARTIS AG; DANA FARBER CANCER INSTITUTE INC.

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dougan, Michael Brookline, US 6 46
Dranoff, Glenn Lexington, US 69 943
Firestone, Brant G Westwood, US 5 0
Straub, Christopher S Stow, US 6 3
Zawel, Leigh Weston, US 34 157

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