Method for modulating process mediated by farnesoid activated receptors
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United States of America Patent
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Oct 21, 2008
Grant Date -
Dec 28, 2006
app pub date -
Apr 28, 2006
filing date -
Jan 13, 1995
priority date (Note) -
Expired
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Abstract
Farnesyl pyrophosphate, the metabolically active form of farnesol, is a key precursor in the synthesis of cholesterol, carotenoids, steroid hormones, bile acids and other molecules involved in cellular growth and metabolism. A nuclear receptor has been identified that is transcriptionally activated by farnesol and related molecules. This novel signaling pathway can be modulated by the use of key metabolic intermediates (or analogs and/or derivatives thereof) as transcriptional regulatory signals.
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