Methods and compositions for diagnosing and treating glaucoma

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 11752117
APP PUB NO 20220249410A1
SERIAL NO

17728167

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Provided herein are methods of treating glaucoma in a patient, comprising: obtaining a biological sample from the patient; testing the biological sample for presence of a mutation in Kir6.2 protein or KCNJ11 gene and a mutation in the Aquaporin-9 protein or AQP-9 gene; and provided that the biological sample tests positive for the presence of a mutation in Kir6.2 protein or KCNJ11 gene and a mutation in the AQP-9 gene or aquaporin-9 protein, administering to the patient a therapeutically effective amount of a sulfonylurea such as tolbutamide or a physiologically equivalent salt or solvate thereof and a pharmaceutically acceptable carrier. Also provided herein are methods of maintaining and/or improving eye health in a subject, comprising: administering to the patient a therapeutically effective amount of tolbutamide or a physiologically equivalent salt or solvate thereof, and a pharmaceutically acceptable carrier.

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International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Sorgente, Nino Washington, US 11 194
Thumann, Gabriele Cologny, CH 5 22

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