Expression of cloned genes in the lung by aerosol and liposome-based delivery
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United States of America Patent
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Oct 22, 2002
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app pub date -
Jan 14, 1998
filing date -
Dec 17, 1991
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Abstract
Methods and compositions for producing a mammal capable of expressing an exogenously supplied gene in cells of the airway are disclosed. Liposome-nucleic acid complexes are prepared then delivered via aerosol to the lung airway. The invention provides a direct method for transforming pulmonary cells, treat disorders of the lung, and for delivering substances systematically following expression in the lung.
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