Method for producing oxindoles

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United States of America Patent

PATENT NO 6706890
APP PUB NO 20040014986A1
SERIAL NO

10168848

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention relates to a method for producing 2-oxindoles from the corresponding isatines of formula (I), wherein R can be H, CH.sub.3, phenyl or benzyl and R.sub.1 can be H, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, phenyl phenoxy, halogen, amino, nitro or hydroxy. Said isatines are converted by means of hydrazine hydrate in a polar solvent at a temperature of 15 to 185.degree. C. to form a corresponding isatine hydrazone which directly undergoes further reaction to form the corresponding 2-oxindole of formula (II) by adding diazabicyclooctane and/or diazabicycloundecane and/or ethyldiisopropylamine as a catalyst in temperatures of 100 to 185.degree. C., whereby the produced reaction water is distilled off. According to formula (II), R and R.sub.1 have the aforementioned definitions. The 2-oxindole is isolated from the reaction mixture by distilling off the solvent and by means of crystallisation. ##STR1##

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Patent Owner(s)

  • DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Felfer, Ulfried Linz, AT 6 24
Hendel, Wolfram Leonding, AT 11 82
Schwendinger, Karl Linz, AT 2 13

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