Method of reducing neuronal electrical activity with a potassium channel subunit
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United States of America Patent
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Mar 20, 2007
Grant Date -
Dec 25, 2003
app pub date -
May 15, 2003
filing date -
May 15, 2002
priority date (Note) -
Expired
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Abstract
Methods of reducing the excitability of an excitable cell by transforming an excitable cell with a nucleic acid construct encoding an open rectifier K.sup.+ channel (dORK) (SEQ ID NO:2) or a modified open rectifier K.sup.+ channel (dORK.DELTA.) (SEQ ID NO:4), and expressing the open rectifier K.sup.+ channel in the excitable cell, wherein the excitability of the transformed cell is reduced. Also featured are transgenic animals expressing dORK or dORK.DELTA..
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