HUMAN BIOSENSORS FOR DETECTING VOLTAGE CHANGES
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United States of America Patent
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Dec 27, 2016
Grant Date -
Jan 19, 2017
app pub date -
Sep 12, 2016
filing date -
Sep 5, 2013
priority date (Note) -
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Abstract
This invention provides biosensors, cell models, and methods of their use for monitoring heme, oxygen or ATP. Biosensors can include targeting domains, sensing domains and reporting domains. Biosensors can be introduced into cells reprogrammed to represent experimental or pathologic cells of interest. Model cells expressing the biosensors can be contacted with putative bioactive agents to determine possible activities.
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