Antagonistic CD40 monoclonal antibodies and uses thereof

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 11926673
APP PUB NO 20220144962A1
SERIAL NO

17579468

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The disclosure provides for antibodies that bind CD40, including a humanized antibody. The antibodies bind CD40 and do not exhibit CD40 agonist activity. The antibodies may comprise a modified IgG1 Fc domain, and exhibit minimal activation of immature dendritic cells. Compositions comprising antibodies, methods of use for treatment of diseases involving CD40 activity, and use in the preparation of a medicament for treatment of a disease involving CD40 activity are provided.

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Patent Owner(s)

  • BRISTOL-MYERS SQUIBB COMPANY

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Krystek,, Jr Stanley R Ringoes, US 9 15
Nayeem, Akbar Newtown, US 17 66
Rakestraw, Ginger Somerville, US 12 15
Struthers, Mary Edison, US 16 29
Yamniuk, Aaron Vancouver, CA 21 108

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