Single-molecule protein and peptide sequencing

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United States of America

PATENT NO 11971417
APP PUB NO 20230305017A1
SERIAL NO

18046012

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Abstract

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The present description provides methods, assays and reagents useful for sequencing proteins. Sequencing proteins in a broad sense involves observing the plausible identity and order of amino acids, which is useful for sequencing single polypeptide molecules or multiple molecules of a single polypeptide. In one aspect, the methods are useful for sequencing multiple polypeptides. The methods and reagents described herein can be useful for high resolution interrogation of the proteome and enabling ultrasensitive diagnostics critical for early detection of diseases.

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Patent Owner(s)

  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Boyden, Edward Stuart Chestnut Hill, US 30 692
Choueiri, Alexi Georges Chandler, US 2 7
Estandian, Daniel Masao Cambridge, US 3 7
Wassie, Asmamaw Boston, US 10 129

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