Genetic inhibition of double-stranded RNA

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United States of America Patent

PATENT NO 8283329
APP PUB NO 20080248576A1
SERIAL NO

11905368

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Abstract

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A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.

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Patent Owner(s)

  • CARNEGIE INSTITUTION OF WASHINGTON;UNIVERSITY OF MASSACHUSETTS

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Driver, Samuel E Boston, US 13 1734
Fire, Andrew Z Washington, US 4 22
Kostas, Stephen A Washington, US 2 22
Mello, Craig C Boston, US 26 2143
Montgomery, Mary K Washington, US 2 22
Tabara, Hiroaki Boston, US 15 1786
Timmons, Lisa Washington, US 11 1733
Xu, SiQun Washington, US 24 1784

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