EPA conjugate vaccine

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United States of America Patent

PATENT NO 8202520
SERIAL NO

12790258

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Abstract

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This invention relates to conjugates of the Vi polysaccharide of S. typhi with the carrier Pseudomonas aeruginosa recombinant exoprotein A (rEPA), and compositions thereof, and to methods of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, S. typhi bacterial infections. The conjugates, and compositions thereof, are useful as vaccines to induce serum antibodies against S. typhi and are useful to prevent and/or treat illnesses caused by S. typhi.

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Patent Owner(s)

Patent OwnerAddress
THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICESOFFICE OF TECHNOLOGY TRANSFER NATIONAL INSTITUTES OF HEALTH 6701 ROCKLEDGE DRIVE SUITE 700 MSC 7788 BETHESDA MD 20892-7788

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kossaczka, Zuzana Bethesda, US 9 32
Robbins, John B Chevy Chase, US 46 313
Schneerson, Rachel Bethesda, US 36 168
Shiloach, Joseph Rockville, US 14 260
Szu, Shousun Chen Bethesda, US 12 50

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