Nucleosides having bicyclic sugar moiety
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United States of America Patent
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Jun 11, 2002
Grant Date -
N/A
app pub date -
Dec 1, 1999
filing date -
May 26, 1998
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Abstract
Conformationally restricted 2', 4'--bridged nucleoside analogues are described herein. The compounds can be prepared by cyclization at C2' and C4' of nucleosides through a linker or linking molecule. These novel nucleosides have a desired, locked sugar pucker and are potentially useful as pharmaceutical ingredients. Oligonucleotides composed of these novel nucleosides are useful for oligonucleotide therapeutic and diagnostic compounds.
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