Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases

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United States of America Patent

PATENT NO 11439666
APP PUB NO 20190046579A1
SERIAL NO

16173875

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Disclosed herein are methods and compositions for inactivating TCR genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain in conditions able to preserve cell viability. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided. Disclosed herein are also methods and compositions for expressing a functional exogenous TCR in the absence of endogenous TCR expression in T lymphocytes, including lymphocytes with a central memory phenotype. Polynucleotides encoding exogenous TCR, vectors comprising polynucleotides encoding exogenous TCR and cells comprising polynucleotides encoding exogenous TCR and/or cells comprising exogenous TCR are also provided.

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Patent Owner(s)

  • SANGAMO THERAPEUTICS, INC.; OSPEDALE SAN RAFFAELE SRL

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bonini, Maria Chiara Milan, IT 15 355
Genovese, Pietro Milan, IT 13 360
Gregory, Philip D Richmond, US 75 3084
Holmes, Michael C Richmond, US 87 3638
Naldini, Luigi Milan, IT 49 1057
Paschon, David Richmond, US 62 1919
Provasi, Elena Milan, IT 5 231
Zhang, Lei Richmond, US 2506 17995

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