AXL-targeting antibody, antibody-drug conjugate, preparation method therefor, and use thereof

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United States of America Patent

PATENT NO 11939386
APP PUB NO 20210214447A1
SERIAL NO

17055499

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Abstract

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Disclosed are a new AXL-targeting monoclonal antibody and antibody-drug conjugate. Also disclosed is a method for preparing said antibody and antibody-drug conjugate. The AXL antibody of the present invention can bind with purified human AXL protein and multiple AXL on tumor cell surface with high effectiveness and high specificity. Said humanized antibody also has high affinity and low immunogenicity. Said AXL antibody-drug conjugate has markable performance against tumors having high AXL expression.

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Patent Owner(s)

  • SHANGHAI INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF SCIENCES

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Lin Shanghai, CN 651 3673
Du, Zhiyan Shanghai, CN 2 2
Jin, Rui Shanghai, CN 20 69
Ma, Lanping Shanghai, CN 7 3
Meng, Tao Shanghai, CN 14 6
Pei, Jinpeng Shanghai, CN 1 0
Shen, Jingkang Shanghai, CN 21 43
Wang, Xin Shanghai, CN 1351 12709
Yu, Ke Shanghai, CN 48 500
Yu, Ting Shanghai, CN 65 670
Zhang, Yongliang Shanghai, CN 25 69

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