Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase

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United States of America Patent

PATENT NO 8063224
APP PUB NO 20080132542A1
SERIAL NO

11998501

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Azacycloalkane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

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Patent Owner(s)

  • MERCK CANADA INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lachance, Nicolas Pierrefonds, CA 22 224
Leclerc, Jean-Philippe Laval, CA 16 63
Li, Chun Sing Dollard-des-Ormeaux, CA 43 233
Ramtohul, Yeeman K Pierrefonds, CA 25 92

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