Cyclic diamine compound and pharmaceutical containing the same
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United States of America Patent
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Jan 16, 2007
Grant Date -
Jul 28, 2005
app pub date -
Jan 26, 2004
filing date -
Jan 26, 2004
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention relates to 2-[4-[2-(7-trifluoromethylbenzoxazol-2-ylthio)ethyl]piperazin-1-yl]-N-[4--hydroxy-2,6-bis(trifluoromethyl)phenyl]acetamide or salt thereof, and an intermediate for the preparation thereof.The above-described compound has both an inhibitory action on ACAT in the artery wall and remarkably high metabolic resistance in human liver microsomes, and exhibits excellent effects for suppressing lipids depression in aorta in vivo so that it is useful as a highly effective preventive or remedy for hyperlipidemia and arteriosclerosis with less side effects.
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