Method for detecting a biological entity in a sample
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United States of America Patent
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Jul 4, 2006
Grant Date -
May 20, 2004
app pub date -
Jul 30, 2003
filing date -
Feb 18, 2000
priority date (Note) -
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status (Latency Note)
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Abstract
The invention relates to the detection of a biological entity in a sample. More particularly, the invention relates to detection of specific pathogens from a possible presence of hundreds to thousands of distinct biological species. The invention provides new assays that can detect the presence of one or more biological entity in a sample out of a possible number of hundreds to thousands of distinct biological species. The method according to the invention for detecting a biological entity in a sample comprises randomly amplifying nucleic acids in the sample to produce labeled nucleic acids; hybridizing the labeled nucleic acids to an array of predetermined nucleic acids; and detecting the labeled nucleic acids that have hybridized to the array.
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