Peptide compounds derived from boronic acid
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United States of America Patent
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Aug 22, 1995
Grant Date -
N/A
app pub date -
Feb 22, 1994
filing date -
Feb 24, 1993
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
A compound of formula (I): ##STR1## in which: R.sub.1 represents hydrogen or acyl, alkyl, benzyl, alkoxycarbonyl, benzyloxycarbonyl, phenoxycarbonyl, 5-[(dimethyl)amino]naphthylsulfonyl, alkoxycarbonylmethyl or carboxymethyl, R.sub.2 represents hydrogen or phenyl, substituted or unsubstituted benzyl, 3-thienylmethyl, 2-pyridylmethyl, diphenylmethyl, fluorenyl, naphthylmethyl, benzocyclobutyl, (dicyclopropylmethyl)methyl, indanyl or (C.sub.3 -C.sub.7 cycloalkyl)methyl, R'.sub.2 represents hydrogen or benzyl or alternatively R.sub.2 and R'.sub.2 together represent C.sub.6 H.sub.5 --CH.dbd., R.sub.3 represents substituted alkyl or guanidinophenyl, amidinophenyl, aminophenyl, guanidinobenzyl, amidinobenzyl, aminobenzyl or cycloalkyl, R.sub.4 and R.sub.5 each represent hydrogen or alkyl, or ##STR2## forms a boronic ester of pinanediol, A represents any one of the groups as defined in the description. Medicinal products.
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