Toxicity management for anti-tumor activity of CARs

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 11273219
APP PUB NO 20180243411A1
SERIAL NO

15963728

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Abstract

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The present invention provides compositions and methods for treating cancer in a patient. In one embodiment, the method comprises a first-line therapy comprising administering to a patient in need thereof a genetically modified T cell expressing a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain and monitoring the levels of cytokines in the patient post T cell infusion to determine the type of second-line of therapy appropriate for treating the patient as a consequence of the presence of the CART cell in the patient.

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Patent Owner(s)

  • THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; THE CHILDREN'S HOSPITAL OF PHILADELPHIA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Grupp, Stephan Havertown, US 8 106
June, Carl H Merion Station, US 193 6618
Kalos, Michael D Philadelphia, US 92 1775
Levine, Bruce L Cherry Hill, US 40 1397

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