Calmodulin inhibitors, Chk2 inhibitors and RSK inhibitors for the treatment of ribosomal disorders and ribosomapathies

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United States of America

PATENT NO 11944625
SERIAL NO

17175079

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Abstract

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The present invention relates to methods, compositions and kits for treatment of ribosomal disorders and ribosomopathies, e.g. Diamond Blackfan anemia (DBA). In some embodiments, the invention relates to the use of novel classes of compounds, i.e. inhibitors of RSK (p90S6K); inhibitors of p70S6K; and inhibitors of rps6, to treat ribosomal disorders and ribosomopathies. In some embodiments, the invention relates to the use of specific Chk2 inhibitors and to the use of specific phenothiazine derivatives to treat ribosomal disorders and ribosomopathies, e.g. DBA.

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Patent Owner(s)

  • THE CHILDREN'S MEDICAL CENTER CORPORATION; DANA FARBER CANCER INSTITUTE INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bradner, James Weston, US 40 640
Buckley, Dennis Cambridge, US 38 901
Macari, Elizabeth Wilmington, US 2 1
Qi, Jun Sharon, US 207 2385
Zon, Leonard I Brookline, US 44 157

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