Tumor suppressor gene

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United States of America Patent

PATENT NO 5559023
SERIAL NO

08384850

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A detailed genetic map on human chromosome 11 was prepared. Then, a commonly deleted region on the chromosome in the tumor tissues of patients with multiple endocrine neoplasia type 1 was identified. Further, by linkage analysis of a family line with this disease, a genetic cause for this disease was localized. A gene present in the region common to these observations was cloned and the structure of this gene was determined. Because a protein coded by this DNA is homologous with those of transcriptional factors, it is expected that the above-mentioned gene may be a novel tumor suppressor gene. Further, it is also expected that the above-mentioned gene and a protein coded for thereby may be useful in preparation of a remedy for cancer and a diagnostic drug for cancer.

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Patent Owner(s)

  • CANCER INSTITUTE;EISAI R&D MANAGEMENT CO., LTD.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Imai, Takashi Chiba, JP 252 2529
Nakamura, Yusuke Kanagawa, JP 404 2976

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