Fusion proteins containing luciferase and a polypeptide of interest

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United States of America Patent

PATENT NO 10829770
SERIAL NO

16571616

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Abstract

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Polynucleotides encoding fusion proteins contain a secretable luciferase fused to a modified polypeptide of interest are disclosed. The polypeptide of interest has been modified to remove a native N-terminal secretion sequence and has been replaced by the secretable luciferase. One example of a modified polypeptide of interest is interferon. The polynucleotides and fusion proteins have biotherapeutic, diagnostic, and quality control applications in biotechnological, medical, and veterinary fields. Methods for producing the secretable fusion protein are also disclosed.

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Patent Owner(s)

  • THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF HOMELAND SECURITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Puckette, Michael Waterford, US 14 43
Rasmussen, Max V Guilford, US 6 31

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